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doi: 10.1007/s40263-015-0301-8 24 MuscogiuriGDeFronzoRAGastaldelliAHolstJJ

RUNX-2 and galectin-3, which regulate cardiovascular pathology, were upregulated along with caspase-1, an essential component of the inflammasome complex, suggesting potential health MP risk [71]

These adaptations persist for years after weight loss, making maintenance without pharmaceutical support extremely challenging