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At the cellular level, Tirzepatide binding to GLP-1 receptors in the hypothalamus directly modulates hunger and satiety signaling
A range of studies have indicated the presence of specialized obesity-associated gut microbiota which may favor production of microbial fermentation products and metabolites increasing efficiency of energy harvest from ingested nutrients as well as modulating gut motility, permeability and immune function 9,10,11,12,13
Mice fed an iron-rich diet developed increased insulin resistance leading to a 40% increase in fasting glucose, as well as three-fold higher triglycerides [5]
However, the evidence remains limited as the medication is relatively new, and individual responses to medications vary
