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Vukojevic J, et al
2013;164:e1737 Alam M, Ghosh S
From Pubchem IUPAC Name: (2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide Synonyms: Aib-His-2Nal-Phe-Lys-NH2 Molecular Formula: C38H49N9O5 Molecular Weight: 711.9 g/mol Sequence: XHXFK CAS number: 170851-70-4 PubChem CID: 9831659 Ipamorelin was identified in 1998 as the first synthetic growth hormone secretagogue to target the selective release of growth hormone as compared to GHRP
Murine models based on Tymp / /Upp / genes double knock-out have been developed to study MNGIE but displayed inconsistencies with the clinic likely due to differences in the deoxyribonucleoside metabolism between humans and mice (Haraguchi et al., 2002)
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