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Recent Major Changes Indications and Usage for Zepbound ZEPBOUND is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist indicated in combination with a reduced-calorie diet and increased physical activity: to reduce excess body weight and maintain weight reduction long term in adults with obesity or adults with overweight in the presence of at least one weight-related comorbid condition
doi: 10.1038/mp.2016.3 68 HaapakoskiR.EbmeierK
Published March 19, 2026
Structure- and regulation-guided LYTAC strategies Beyond receptor selection, the structural and regulatory design of LYTACs critically shapes their degradation behavior and therapeutic potential by influencing stability, intracellular trafficking, and target engagement
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