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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)
They slow gastric emptying (an effect that may diminish over time), increase feelings of fullness, and reduce hunger signals to the brain, thereby facilitating calorie reduction and subsequent weight loss
Oral tablets take much longer to work, while topical creams are the least effective due to poor skin absorption
Patients considering GLP-1 receptor agonist or dual GIP/GLP-1 therapy should understand that these medications facilitate weight loss through appetite reduction and decreased food intake, not by "speeding up metabolism" or burning additional calories at rest
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