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(PubMed) Hankey GJ

TAT-PTD, penetratin and polyarginine are generally categorized as cationic CPPs ( in vitro insulin delivery across the intestinal epithelium ( via active and transcytosis-like mechanisms (Violini et al., 2002), and in intestinal insulin absorption from the ileum in rats ( in vitro study of epithelial transport of insulin by D-form of arginine octamer (D-R8) indicated that cellular uptake is the critical step for efficient epithelial absorption and showed that D-R8 mediates intestinal epithelial transport of insulin by energy-independent unsaturable uptake ( Biotinylated transportan and its analog transportan 10 were reported to pass through epithelial Caco-2 monolayer cells mainly via transcellular transport and partly via paracellular pathway, while penetratin passes across cell monolayers in low yields, possibly due to partial degradation ( via energy-dependent pathway, involving electrostatic interactions between anionic proteoglycans in membrane and cationic D-R6 peptide

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