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In trials, the drug caused thyroid C-cell tumors in rodents, although it is unknown whether Zepbound can result in the same cancer in humans
DiPietro, L., et al
Once bound, the peptide initiates signaling cascades (AMPK activation, FGF23 modulation, insulin sensitivity enhancement) that persist after the parent peptide has dissociated and been eliminated
Although not universally observed, studies suggest that individuals taking semaglutide and tirzepatide may experience a significant loss of lean muscle mass, along with fat mass (15-60% of weight loss)
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