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This isnt because GLP1 medications are inherently dangerous for these patients but because the rapid changes in appetite, body weight, and eating patterns can interact with existing vulnerabilities

At higher exposures these findings were associated with moderate to marked adverse clinical signs (lethargy, abnormal respiration, ataxia, reduced activity, body tone and reflexes) and marked decreases in plasma and CSF glucose levels

Body mass affects the dilution of alcohol in the bloodstream, increasing toxicity risk