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Contrave dampens this brain signal and makes eating fatty food or sugary food less satisfying (less pleasurable) and reduces the urge to comfort eat or crave these foods. Through this study, researchers make the case for a combined approach, using both gut hormone analogs like GLP-1s, and NB-ER at the same time, to treat obesity Combining NB-ER with GLP-1 makes mechanistic sense because GLP-1 primarily makes a person feel full faster and decreases hunger, while NB-ER reduces food cravings, Hussain explained
The MHRA has updated GLP-1 guidance for prescribers and patients and has reminded the public that these medicines are for specific licensed uses, not for casual or cosmetic weight loss
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