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A Phase 1 pharmacokinetic study conducted by Eli Lilly (NCT04050670) specifically examined tirzepatide absorption across all three sites in participants with varying body sizes

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However, contact your healthcare provider immediately if you experience: Call Right Away: Severe, persistent vomiting that prevents you from keeping down any fluids Signs of dehydration: dark urine, dizziness when standing, extreme fatigue, confusion Severe abdominal pain that doesn't improve or is getting worse Signs of pancreatitis: intense upper abdominal pain radiating to back, fever, nausea Allergic reaction: rash, swelling, difficulty breathing Low blood sugar symptoms (if you have diabetes): shaking, sweating, confusion, blood sugar below 70 mg/dL Vision changes (especially if you have diabetes) Call During Office Hours: Nausea so severe you can't eat anything for more than 24 hours Constipation lasting more than 4-5 days despite interventions Persistent heartburn not relieved by over-the-counter medication Questions about adjusting other medications (especially diabetes meds) Concerns about whether your symptoms are normal Normal First-Week Symptoms (Don't Need to Call): Reduced appetite Mild to moderate nausea, especially days 2-4 Feeling full very quickly Mild fatigue Some constipation Mild headaches Food aversions or different taste preferences Frequently Asked Questions What should I eat during my first week on Ozempic or Wegovy