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Combining the two might theoretically exacerbate digestive symptoms in susceptible individuals, though this has not been systematically studied
Fat is the primary target
151 While preclinical/clinical studies suggest that the dual/pan-PPAR agonists have a more significant effect in the treatment of disease when compared with PPAR or PPAR agonists alone, improvement of the low agonistic activity and low metabolic stability of multiple agonists may still need to be improved
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