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Long-Term Side Effects GLP-1 medications have been in use for almost 20 years, beginning with exenatide in 2005
Zepbound, which mimics a second hormone called gastric inhibitory polypeptide (GIP) in addition to the GLP-1, comes in an injectable, prefilled, single-use pen for just over $1,000 per pen
Like the injection, the Wegovy pill tends to use a gradual dose escalation
There is also growing interest in whether these medications have tissue-level anti-inflammatory effects beyond weight loss alone
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