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Reactivation of the totally inactive pancreatic lipase RP1 by structure-predicted point mutations

TRIUMPH-1 (80 Weeks) The pivotal TRIUMPH-1 obesity trial (2,339 adults, no diabetes), presented at ADA 2026, extended the treatment window to 80 weeks and produced the largest pivotal weight-loss readout to date: Among the 12 mg group, 45.3% lost at least 30% of their body weight and 65.3% ended the trial with a BMI below 30

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The bigger picture: endometriosis and metabolic health The GLP-1 and endometriosis connection is part of a larger scientific shift toward understanding endometriosis as a systemic metabolic and inflammatory disease rather than a purely reproductive condition