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JAMA 282:15681575 Clemmensen C, Chabenne J, Finan B et al (2014) GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet

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Yes, though a moderate interaction exists

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In particular, KEAP1 and NRF2 mutations are encountered in 2030% of non-small cell lung cancers (Cancer Genome Atlas Research Network 2012

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