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Semaglutide was initially developed for glycemic control and designed to mimic the glucose-lowering effects of GLP-1 through enhanced pharmacokinetics [1]
Pen Design and Packaging This might seem trivial, but the pen designs differ slightly
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This makes sense since both molecules are designed to activate the GLP1 Receptor (receptor activation is based on molecule shape): If the impurity does not have similar molecular characteristics as the target, it will not show up in HPLC analysis
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