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[16] [18] These metabolites, including cyclic 3-hydroxymelatonin, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK), and N1-acetyl-5-methoxykynuramine (AMK), contribute to the broader antioxidative effects of melatonin through further redox reactions with free radicals
The Phase 2 trials enrolled people with a BMI of 27 or higher with at least one weight-related condition, or a BMI of 30 or higher without additional conditions
doi: 10.1210/jc.2010-2679 47 HjelholtAJLeeKYArlien-SborgMCPedersenSBKopchickJJPuriVet al
FGF21, a protein implicated in fat and sugar utilization, decreased at higher doses, which may indicate enhanced metabolism
