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Cleaning reaction After the deprotection reaction is completed, add an appropriate amount of water and organic solvent (such as DMF), stir evenly, let it stand for layering, discard the water layer, and wash repeatedly to remove residual deprotection reagents and other impurities

Etiology Genetics COL5A1 or COL5A2 mutation in 40-50% less common mutations identified below Associated conditions Connective tissue disorder characterized by hyperelastic/fragile skin joint hypermobility and dislocation generalized ligamentous laxity poor wound healing early onset arthritis additional features Classification Berlin Classification (1988) - revised Types I - XI exist Types II and III - most common and least disabling Villefranche Classification (1998) Presentation Symptoms double-jointedness easily damaged, bruised, & stretchy skin easy scarring & poor wound healing increased joint mobility, joint popping, early arthritis especially shoulders, patellae, ankles chronic musculoskeletal pain (50%) Physical exam a score of 5 or more on 9-point Beighton-Horan scale defines joint hypermobility

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[7] This article walks through what the FDA actually proposed, what the proposal does not do, and what you should ask if you are using a compounded GLP-1 today