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The antioxidant action of DTPA is derived from its ability to chelate Fe 3+ and thus prevent its reaction with superoxide and hydrogen peroxide, leading to formation of hydroxyl radicals (i.e., preventing HaberWeiss and Fentons reactions) ( 3+ DTPA is slowly reduced by superoxide, which results in the production of fewer hydroxyl radicals (Rahhal and Richter, 1988)
Previous studies showed that bladder urothelial cells express multiple G-protein-coupled receptors, implicating them in homeostasis, injury responses and potential therapeutic targeting 13
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