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Brcic L et al
User 19 experienced no meaningful benefit whatsoever for chronic lumbar pain despite using both compounds
The specific thresholds that should prompt dose reduction or discontinuation include: ALT or AST elevation exceeding 3 times the patient's baseline value, new or worsening coagulopathy (INR increase of 0.5 or more from baseline), albumin decline below 2.5 g/dL, or new clinical signs of hepatic decompensation such as worsening ascites, encephalopathy, or jaundice [5]
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