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Laron Z, Lilos P, Klinger B

Glucagon-like peptide 1 (GLP-1) can reverse AMP-activated protein kinase (AMPK) and S6 kinase (P70S6K) activities induced by fluctuations in glucose levels in hypothalamic areas involved in feeding behaviour

Dr Blauvelt: Both the TOGETHER-PsO and the TOGETHER-PsA trial required that the patients be overweight with a risk factor or be classically categorized as obese