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For example, patients who struggle with post-meal glucose spikes may benefit from the dual action of these drugs

Absolute contraindications Medullary thyroid cancer MEN-2 Pregnancy or breastfeeding Prior severe allergic reaction to GLP-1 medications Conditions requiring extra caution Gastroparesis or delayed gastric emptying History of pancreatitis Advanced diabetic retinopathy Use alongside medications that increase hypoglycemia risk These and a few other situations require individualized assessment, which is why specialty endocrine care matters

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It has been reported that K-Ras-driven mouse lung tumors preferentially utilize glucose more than glutamine to supply carbon to the TCA cycle via pyruvate carboxylase 192