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As research progresses, the hope is that some of these biologic modalities will enter clinical practice, especially in high-stakes surgeries (transplantation, cardiac surgery, major trauma) where current supportive care is not always sufficient to prevent organ injury
As people grow older, their collagen becomes fragmented, fibroblast function These changes, along with the loss of another key structural protein called elastin, lead to signs of aging such as sagging skin and wrinkles
Consequently, BCL-2 family inhibitors have been identified to function as senolytics, including ABT-737, ABT-263 (Navitoclax), A-1331852, and A-1155463
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