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Dosing begins at a low weekly amount and increases gradually for safety
Clinical considerations for cost-conscious prescribing include discussing realistic expectations about treatment duration and total cost, exploring alternative medications with generic availability (such as metformin or sulfonylureas for diabetes), and emphasizing lifestyle modifications that may reduce medication dependence
In severe cases, not being able to urinate at all (a medical emergency)
GLP-1 agonists like semaglutide and tirzepatide are administered once weekly, and the day of the week does not significantly matter
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