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aggressive mixing can damage the molecular structure and reduce potency
For instance, many AD patients display behavioral symptoms such as rest-activity rhythm fragmentation [176], sundowning (characterized by recurring confusion or agitation in the late afternoon or early evening) [177], and disturbances in sleep and wake maintenance [178]
Semin Cell Dev Biol 2012
Solid lipid nanoparticles for drug delivery: pharmacological and biopharmaceutical aspects
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