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Liraglutide improved learning and memory performance, attenuated hyperphosphorylation of tau as well as NFs, and prevented neurodegeneration via improving JNK and ERK signaling in brain of 3Tg mice (232)
No consistent pattern was seen with the median t max across the groups (72, 48, 48 and 60 h for normal renal function and mild, moderate and severe renal impairment, respectively)
Mild cognitive impairment (MCI), characterized by deficits beyond that anticipated for an individuals age and education, but without functional impairment, is often the earliest clinical stage of AD [4]
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