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The overflow of downstream effects erupting after the occurrence of an acute stroke include, among others, energy failure and electrochemical shifts (Dirnagl et al., 1999), metaplasticity (Murphy and Corbett, 2009), the activation of molecular, multi-omics pathways (Montaner et al., 2020), immune responses (Chamorro et al., 2012), as well as neurodegeneration (Castillo et al., 2019)

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This is not a reason to avoid all vitamin C products, but it is a formulation chemistry consideration that routine combination skincare advice routinely omits