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1 Introduction A major challenge of the 21st century is to sustainably nourish the rapidly growing global population amid increasing resource scarcity

The follicle shrinks, the anagen (growth) phase of the hair cycle shortens, and the hair produced becomes progressively finer and shorter until, eventually, the follicle goes dormant and stops producing hair altogether

While they are frequently stacked together, they operate through distinct molecular pathways

Melatonin Melatonin, a hormone synthesized primarily by the pineal gland and locally in skin cells, plays a critical role in protecting melanocytes from oxidative stress by acting as a potent antioxidant and modulating cellular defense mechanisms 196