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Key observations from the trial data include: Responder rates were high but not universal some individuals lost less than 5% of body weight even at therapeutic doses

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12 Oxidative stress, 13 mitochondrial dysfunction, 14 and endoplasmic reticulum (ER) stress 15 are all involved in NDs induced by brain IR

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Those ice crystals physically pierce and tear apart protein structures

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So theres a lot of interest in that receptor

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