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The possible molecular mechanism underlying OPs anti-photoaging is possibly related to downregulating of the MAPK/NF-B signaling pathway, while promoting TGF- production in the skin
MC1R is the primary melanocortin receptor governing skin pigmentation and expressed on melanocytes, keratinocytes, fibroblasts, and immune cells in the skin , whose activation by -MSH drives melanin synthesis, melanocyte dendritic extension, photoprotective eumelanin production, and anti-inflammatory signalling in response to ultraviolet radiation
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