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Discontinuation rates due to adverse effects remain relatively low, with approximately 6% of Zepbound users and 8% of Wegovy users stopping treatment ^2

The tirzepatide weight loss timeline tends to show slightly faster results at comparable time points due to its dual mechanism of action

21, 22 Further, ROS production has been demonstrated to occur not only in the endothelial cell layer but also within the media and adventitia, all of which may impair NO signaling within vascular tissues

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