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Melanotan 1 is the research name for the -MSH analog developed into the drug afamelanotide, which is marketed under the brand name SCENESSE
14 Anti-inflammatory Effects GLP-1RAs reduce proinflammatory cytokines, including tumour necrosis factor- and interleukin-6
However, in contrast to anti-hyperlycemic agents such as metformin, pioglitazone and peroxisome proliferator-activated receptor gamma (PPAR) agonists, which were particularly well studied in this matter, very few clinical studies concerning the effects of GLP-1R targeting therapeutics on alleviation of depressive symptoms in humans have been carried out so far [118, 119]
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