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The answer depends on which specific GLP-1 medication you're using
In short, an injection will provide a higher dose of B12 at regular intervals, whilst oral supplements have a lower dosage and can be taken every day
IL-1, on the other hand, has been shown to interfere with the ion selectivity of tight junctions (Coyne et al., 2002), and, in combination with High Mobility Group Box 1 (HMGB1), induces the downregulation of occludin and claudin-1 and the mislocalization of E-cadherin and -catenin (HUANG et al., 2016)
Blocking both receptors by co-infusion of the incretin receptor antagonists deteriorated glucose tolerance [42], illustrating the importance of the incretin system in humans
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