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Rybelsus falls under the category of drugs known as glucagon-like peptide 1 (GLP 1) receptor agonists23

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This is consistent with research suggesting that these drugs broadly reduce neuroinflammation, which may also be a mechanism through which they improve anxiety and depression and reduce suicidality

Current medical understanding suggests these changes are more likely linked to hormonal shifts that can occur during rapid weight loss rather than a direct effect of the medicine