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IGF-1 displays more binding sites for SHP2 (a phosphatase related to growth) and seems more prone to recruit Cbl [121] (an E3 ligase that targets the receptor for ubiquitination and destruction) and thus may explain a different regulatory mechanism not mediated by serine phosphorylation, and thus not so sensitive to metabolic derangements
Available in the form of capsules, tablets, or sublingual sprays, oral supplements are a more accessible and affordable option compared to injections
Cycle length: 4 to 8 weeks for acute injuries
Animals were exposed to standard chow or an HFD during metabolic assessment (as indicated)
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