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In order to calculate the similarity between molecules, a new graph that contains information regarding the two molecules is required, allowing for better and faster comparisons to solve an optimization problem known as the Maximum Independent Set (MIS) that extracts the similar parts of those two graphs, explains the team

This isnt theoretical we see it clinically

The SURMOUNT-5 trial showed that maximum-dose tirzepatide produces about 47% more weight loss than maximum-dose semaglutide, so they are clearly not equivalent at their respective maximums