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It has a higher molecular weight (4,813 versus 4,114 Daltons)
With doses of 10 nmol/kg and higher, rats exhibited not only a lack of activity, but also notable changes in facial expressions associated with pain and nausea including orbital tightening and nose/cheek flattening compared to rats treated with vehicle alone
Phase 3 trials are still running, and Eli Lilly is expected to submit retatrutide for regulatory approval once the remaining trials report results across 2026
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