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Melanotan 1 , also known as afamelanotide, is a selective agonist of the melanocortin 1 receptor (MC1R)
It directly neutralizes reactive oxygen species (ROS) the unstable molecules responsible for oxidative stress and regenerates other antioxidants like vitamins C and E
Nonetheless, 3DVA of CTR complexes bound to either Cagri or CagriBB revealed transitions between the two major alternative conformations (Supplementary Fig
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