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This amino acid trio makes glutathione a so-called tripeptide from a chemical point of view
Since insulin therapy often indicates more advanced disease progression, greater severity, or additional comorbidities, which may lead to a higher risk of intestinal obstruction, and there was no statistically significant difference in intestinal obstruction risk between GLP-1RAs and other anti-diabetic medications (e.g., SGLT2 inhibitors, metformin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors), the observed reduction relative to insulin does not necessarily suggest a protective effect of GLP-1RAs against intestinal obstruction
In the UK, this may include referral to a specialist weight management service or consideration of approved pharmacological treatments, in line with NICE guidance: Semaglutide (Wegovy) is recommended by NICE (TA875) for weight management in adults meeting defined BMI and comorbidity criteria, when used as part of a specialist weight management service
Future studies are needed to assess frailty and physical dysfunction by using other objective tools such as the Fried frailty phenotype and Short Physical Performance Battery Score to confirm the robustness of our study findings with respect to greater treatment benefit of semaglutide in frail patients and improvement in frailty burden with semaglutide
