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At the same time, the pleiotropic, neurotrophic and neuroprotective properties of GLP-1RAs are also obvious and, taking into account the ability to enhance the energy metabolism of neurons and optimize synaptic plasticity these beneficial effects position GLP-1RAs as potential agents modifying brain diseases [109, 110]

This is particularly beneficial for individuals struggling to achieve weight loss through diet and exercise alone

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Published human exposure is limited to pharmacokinetic/pharmacodynamic study and a completed Phase II trial