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[7] (This interaction is not significant when levodopa is combined with carbidopa, as in standard carbidopa/levodopa therapy, because carbidopa prevents peripheral levodopa breakdown.) Another notable interaction involves the chemotherapeutic agent altretamine: coadministration of pyridoxine can decrease altretamines effectiveness and is generally advised against unless specifically directed

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Notwithstanding the impressive results that have been published to date, there is still a requirement for successful human trials to be completed prior to clinical translation

What I found was quite the opposite: Some patients lost a minor amount of weight (a few pounds here and there) but many suffered from side effects that made them stop taking the medication