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Variants of OXM resistant to DPP-IV (achieved by addition of PEG [86], fatty acids [87], substitution of certain amino acids [85] or even combined modifications [88]) have been advanced to circumvent the limited clinical potential of the native peptide
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In some cases, temporary dose reduction or switching to an alternative GLP-1 receptor agonist may be considered if side effects are intolerable and cannot be managed through supportive measures
His father was a heating engineer and his mother a pharmacist
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