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Starting with a lower dose and gradually increasing helps minimize discomfort
Free Radic Biol Med 78:4255
restoring these levels helps offset that decline and supports a balanced, regenerative state
In DR, high glucose inhibits Nrf2 activity by activating protein kinase C (PKC) and accumulating advanced glycation end products (AGEs), reducing retinal cell GSH/GPx4 levels, impairing iron export, inducing free iron and LPO accumulation, and activating ferroptosis in Mller, ARPE and endothelial cells, exacerbating vascular leakage (134136)
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