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The teams analysis was simultaneously published in JAMA .[1] Semaglutide and tirzepatide are popular diabetes drugs now being increasingly used for weight loss, even in patients without diabetes
Key safety observations from Phase 2 data include: Gastrointestinal side effects were the most commonly reported adverse events Dose-dependent tolerability issues were noted, particularly at higher doses, with meaningful discontinuation rates Increases in heart rate were observed, consistent with the known class effect of GLP-1 receptor agonists
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