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Article contents Abstract Introduction Urolithin A: sources, dosage and mechanism of action Spermidine: sources, dosage and mechanism of action Urolithin A and spermidine in autophagy and mitophagy: studies in vitro In vivo studies on urolithin A and spermidine Clinical studies on urolithin A and spermidine Conclusions Financial support Competing interests Authorship Consent for publication Declaration of generative AI and AI-assisted technologies in the writing process References Distinct roles of urolithin A and spermidine in mitophagy and autophagy: implications for dietary supplementation Published online by Cambridge University Press: 17 December 2025 Abstract Introduction Urolithin A: sources, dosage and mechanism of action Spermidine: sources, dosage and mechanism of action Urolithin A and spermidine in autophagy and mitophagy: studies in vitro In vivo studies on urolithin A and spermidine Clinical studies on urolithin A and spermidine Conclusions Financial support Competing interests Authorship Consent for publication Declaration of generative AI and AI-assisted technologies in the writing process References Abstract The increasing focus on longevity and cellular health has brought into the spotlight two key compounds, urolithin A (UroA) and spermidine, for their promising roles in autophagy and mitophagy

Symptoms include: Difficulty breathing Chest tightness Widespread rash Severe swelling Any of these requires immediate medical attention

Get the escalation wrong and you either lose efficacy or gain side effects you did not need