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What a Meaningful Certificate of Analysis Should Include Complete chemical name Declared salt and counterion Free-cation and salt molecular weights where relevant Batch number and manufacture date Observed LC-MS result NMR identity evidence Counterion result Quantitative active-content assay Chromatographic purity Named and unknown impurity results Residual-solvent results Water or loss-on-drying result Elemental or inorganic-impurity testing where appropriate Method references and acceptance limits Testing-laboratory identity A clear statement of tests not performed Why 99% Purity Is Not Enough A single chromatographic percentage does not prove that the main peak is the correct positional isomer, that the counterion is correct, that the quantity is calculated properly or that residual solvents and inorganic impurities meet an appropriate specification
2019 May 27;3(2):200-214
How to Give a B12 Injection: Step-by-Step Once youve prepped your space and chosen your injection site, youre ready for the main event
In clinical trials, people using GLP-1 drugs lost an average of about 10 pounds more than people using a placebo
