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Antibiotics worsen the issue as well, stripping away protective bacteria species and giving Candida room to dominate
This can result in the formation of ROS such as O 2 - and hydrogen peroxides (H 2 O 2 ), and potentially can lead to loss of mitochondrial membrane potential (m) ( 2+ via both (1) the import from the extracellular compartment and (2) release from mitochondria and endoplasmic reticulum ( 2+ transport in and out of mitochondria by voltage dependant anion channels (VDAC) and mitochondrial Ca 2+ uniporter (MCU) (Zorov et al., 2014
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