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Expanding the library of 1,2,4-oxadiazole derivatives: discovery of new farnesoid X receptor (FXR) antagonists/pregnane X receptor (PXR) agonists

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One case involved a patient with stage 4 chronic kidney disease treated with an SGLT-2 inhibitor and metformin, who developed euDKA with concomitant lactic acidosis

Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase