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NNMT expression is significantly upregulated in white adipose tissue during obesity (3-5 fold) and increases with age across multiple tissues, creating a metabolic drain on both the NAD+ pool and the methylation budget
Animal-based foods: Clams, sardines, beef liver, tuna, salmon, dairy, and eggs, are highest
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Store reconstituted material refrigerated (28C) and use within ~4 weeks
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