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Histopathological features revealed increased melanin pigmentation in the basal epithelial layer with overlying hyperkeratosis and pigment-laden subepithelial macrophages with normal morphological appearance

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These changes, related to a discrepancy in the growth pattern between the lateral and central nail matrix, resolve spontaneously over time.9,10 Beau's lines These are transverse depressions of the nail plate caused by a temporary interruption of growth in the matrix (Fig

5NX2: 883 3 ), indicating that activation of the TMD occurs through reorganization of the helix bundle rather than the dramatic expansion or shrinkage of the binding pocket