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Lactate is regarded as a central signaling molecule through protein lactylation, interacting with the GPR81 receptor 44,45,46 , or as a circulating substrate for the TCA cycle 21,22

DHPO can inhibit USP7 activity to induce ferroptosis, preventing the invasion and migration of gastric cancer cells

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Animal experiments were approved by the Wako Animal Experiment Committee in RIKEN (approval number: W2021-2-020(1))